Journal article
Increased glucose metabolic activity is associated with CD4 T-cell activation and depletion during chronic HIV infection
CS Palmer, M Ostrowski, M Gouillou, L Tsai, D Yu, J Zhou, DC Henstridge, A Maisa, AC Hearps, SR Lewin, A Landay, A Jaworowski, JM McCune, SM Crowe
AIDS | LIPPINCOTT WILLIAMS & WILKINS | Published : 2014
Abstract
Objectives: Glucose metabolism plays a fundamental role in supporting the growth, proliferation and effector functions of T cells. We investigated the impact of HIV infection on key processes that regulate glucose uptake and metabolism in primary CD4+ and CD8+ T cells. Design and methods: Thirty-eight HIV-infected treatment-naive, 35 HIV+/ combination antiretroviral therapy, seven HIV+ long-term nonprogressors and 25 HIV control individuals were studied. Basal markers of glycolysis [e.g. glucose transporter-1 (Glut1) expression, glucose uptake, intracellular glucose-6-phosphate, and L-lactate] were measured in T cells. The cellular markers of immune activation, CD38 and HLADR, were measured ..
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Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
This research was funded by a 2010 developmental grant (CNIHR) from the University of Washington Center for AIDS Research (CFAR), an NIH funded program under award number AI027757 which is supported by the following NIH Institutes and Centers (NIAID, NCI, NIMH, NIDA, NICHD, NHLBI, NIA), and the Australian Centre for HIV and Hepatitis Virology Research (ACH<SUP>2</SUP>). C.S.P is a recipient of the CNIHR and ACH<SUP>2</SUP> grant. SMC is a recipient of a National Health and Medical Research Council of Australia (NHMRC) Principal Research Fellowship.